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Pharmaceutical intermediate

Acetoacetyl compound Active methylene Acetoacetyl intermediate Agrochemical intermediate

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine structure

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Pyrrolopyrimidine scaffold Heteroaryl chloride Kinase inhibitor building block Pharmaceutical intermediate

3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one structure

3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Pyrrolopyrimidine scaffold Lactam Heteroaryl drug building block Pharmaceutical intermediate

4-ethynyl-1,2-bis(trifluoromethyl)benzene structure

4-ethynyl-1,2-bis(trifluoromethyl)benzene

CAS 2411969-93-0

Bis(trifluoromethyl)benzene Fluorinated building block Ethynyl arene building block Optoelectronic materials

3-Hydroxy-4- nitrobenzoic Acid structure

3-Hydroxy-4- nitrobenzoic Acid

Nitrobenzoic acid scaffold Carboxylic acid Nitro aryl acid building block Pharmaceutical intermediate

3,5-diisopropylphenol structure

3,5-diisopropylphenol

Diisopropylphenol motif Phenol Hindered phenol building block Pharmaceutical intermediate

4-ethynyl-1,2-bis(trifluoromethyl)benzene structure

4-ethynyl-1,2-bis(trifluoromethyl)benzene

CAS 2411969-93-0

Bis(trifluoromethyl)benzene Fluorinated building block Ethynyl arene building block Optoelectronic materials

1,3-dimethyl-5-(methylamino)-4-pyrazolyl o-fluorophenyl ketone structure

1,3-dimethyl-5-(methylamino)-4-pyrazolyl o-fluorophenyl ketone

Pyrazole scaffold Aryl ketone Fluorinated heteroaryl building block Pharmaceutical intermediate

4-(2-amino-2-methylpropyl)phenol structure

4-(2-amino-2-methylpropyl)phenol

Aminophenol motif Phenol Arylamine building block Pharmaceutical intermediate

(S)-(+)-1-Bromo-2-methylbutane structure

(S)-(+)-1-Bromo-2-methylbutane

Chiral alkyl chain Alkyl bromide Chiral alkylating building block Pharmaceutical intermediate

1-bromo-2-(2-methoxyethoxy)ethane structure

1-bromo-2-(2-methoxyethoxy)ethane

Ether chain motif Alkyl bromide Linker building block Pharmaceutical intermediate

2-(4-Bromomethyl)phenylpropionic acid structure

2-(4-Bromomethyl)phenylpropionic acid

CAS 111128-12-2

Arylpropionic acid scaffold Bromomethyl group Aromatic alkylating building block Pharmaceutical intermediate

3-Bromo-5-chloro-4-hydroxyaniline structure

3-Bromo-5-chloro-4-hydroxyaniline

CAS 1158322-54-3

Halogenated aminophenol Aromatic amine Halogenated arylamine building block Pharmaceutical intermediate

3-Methyl-8-quinolinesulphonyl chloride structure

3-Methyl-8-quinolinesulphonyl chloride

Quinoline scaffold Sulfonyl chloride Sulfonylation reagent Pharmaceutical intermediate

2,4-Dichloro-7H-pyrrolo[2,3-d]pyriMidine structure

2,4-Dichloro-7H-pyrrolo[2,3-d]pyriMidine

Pyrrolopyrimidine scaffold Dichloro heteroarene Heteroaryl functionalization precursor Pharmaceutical intermediate

(1R,2S)-2-Fluorocyclopropylaminetosylate

CAS 143062-84-4

Cyclopropane scaffold Fluorinated building block Chiral fluorinated amine building block Pharmaceutical intermediate

2-oxooxolane-3-carboxylic acid structure

2-oxooxolane-3-carboxylic acid

Oxolanone scaffold Carboxylic acid Oxygen heterocycle building block Pharmaceutical intermediate

1,1-Cyclopropanedicarboxylic acid structure

1,1-Cyclopropanedicarboxylic acid

Cyclopropane scaffold Dicarboxylic acid Small-ring diacid building block Pharmaceutical intermediate

tert-Butyl aziridine-1-carboxylate structure

tert-Butyl aziridine-1-carboxylate

Aziridine scaffold Boc-protected amine Aza-small-ring building block Pharmaceutical intermediate

Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate

Piperidine scaffold Ethyl ester Chiral amino acid ester building block Pharmaceutical intermediate

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Piperidine scaffold Carboxylic acid Chiral amino acid building block Pharmaceutical intermediate

3-(4-chlorophenyl)-3-methoxyazetidine;hydrochloride structure

3-(4-chlorophenyl)-3-methoxyazetidine;hydrochloride

CAS 1781544-25-9

Azetidine scaffold Hydrochloride salt Aryl azetidine building block Pharmaceutical intermediate

N-(2,4-ditert-butyl-5-hydroxyphenyl)acetamide structure

N-(2,4-ditert-butyl-5-hydroxyphenyl)acetamide

CAS 1992813-92-9

Hindered phenol motif Acetanilide Aromatic functional building block Pharmaceutical intermediate

N-benzyl-2-chloroethanamine;hydrochloride structure

N-benzyl-2-chloroethanamine;hydrochloride

Benzylamine scaffold Chloroethyl group Alkylating amine building block Pharmaceutical intermediate

4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-2-amine structure

4-Chloro-5H-pyrrolo[3,2-d]pyrimidin-2-amine

CAS 943736-58-1

Pyrrolopyrimidine scaffold Amino heteroarene Kinase inhibitor building block Pharmaceutical intermediate

1-benzylpiperidine-4-carbaldehyde structure

1-benzylpiperidine-4-carbaldehyde

Benzyl substituted Aldehyde Heterocyclic aldehyde building block Pharmaceutical intermediate

3-(Bromomethyl)-1,1-dimethylcyclobutane structure

3-(Bromomethyl)-1,1-dimethylcyclobutane

Cyclobutane scaffold Alkyl bromide Small-ring alkylating building block Pharmaceutical intermediate

1-Amino-3,3-difluorocyclobutanecarboxylic acid structure

1-Amino-3,3-difluorocyclobutanecarboxylic acid

CAS 1225532-86-4

Cyclobutane scaffold Amino acid Fluorinated small-ring building block Pharmaceutical intermediate

2-Oxaspiro[3.3]heptan-6-ylmethanol structure

2-Oxaspiro[3.3]heptan-6-ylmethanol

CAS 1363380-95-3

Oxaspiro scaffold Alcohol Spirocyclic building block Pharmaceutical intermediate

(4,4-Dimethyloxetan-2-yl)methanol structure

(4,4-Dimethyloxetan-2-yl)methanol

Gem-dimethyl substituted Alcohol Oxygenated small-ring building block Pharmaceutical intermediate

2-Methylene-5,8-dioxaspiro[3.4]octane structure

2-Methylene-5,8-dioxaspiro[3.4]octane

Dioxaspiro scaffold Acetal Spirocyclic building block Pharmaceutical intermediate

Tert-butyl 3-amino-3-ethylazetidine-1-carboxylate structure

Tert-butyl 3-amino-3-ethylazetidine-1-carboxylate

CAS 1158758-79-2

Azetidine scaffold Boc-protected amine Heterocyclic amine building block Pharmaceutical intermediate

[(3-Methylidenecyclobutoxy)methyl]benzene structure

[(3-Methylidenecyclobutoxy)methyl]benzene

CAS 1057641-73-2

Methylenecyclobutane scaffold Alkene Small-ring alkene building block Pharmaceutical intermediate

1-Tert-butyl 3-methyl 3-hydroxyazetidine-1,3-dicarboxylate structure

1-Tert-butyl 3-methyl 3-hydroxyazetidine-1,3-dicarboxylate

CAS 1884303-05-2

Azetidine scaffold Boc-protected amine Protected heterocyclic intermediate Pharmaceutical intermediate

2-(Oxetan-3-yl)ethan-1-ol structure

2-(Oxetan-3-yl)ethan-1-ol

CAS 251922-46-0

Oxetane scaffold Alcohol Oxygenated small-ring building block Pharmaceutical intermediate

3-Fluoro-3-methylazetidine hydrochloride structure

3-Fluoro-3-methylazetidine hydrochloride

CAS 1427379-42-7

Azetidine scaffold Fluorinated heterocycle Fluorinated heterocyclic building block Pharmaceutical intermediate

(1-Methylazetidin-3-yl)methanamine structure

(1-Methylazetidin-3-yl)methanamine

CAS 1359656-98-6

Azetidine scaffold Primary amine Heterocyclic amine building block Pharmaceutical intermediate

3-Methyl-3-azetidinecarboxylic acid methyl ester hydrochloride structure

3-Methyl-3-azetidinecarboxylic acid methyl ester hydrochloride

CAS 1114876-08-2

Azetidine scaffold Hydrochloride salt Heterocyclic ester building block Pharmaceutical intermediate

(2S,4S)-4-phenylsulfanylpyrrolidine-2-carboxylic acid;hydrochloride structure

(2S,4S)-4-phenylsulfanylpyrrolidine-2-carboxylic acid;hydrochloride

CAS 105107-84-4

Proline scaffold Carboxylic acid Chiral amino acid building block Pharmaceutical intermediate

3-(Difluoromethyl)azetidine hydrochloride structure

3-(Difluoromethyl)azetidine hydrochloride

CAS 1354792-76-9

Azetidine scaffold Difluoromethyl group Fluorinated heterocyclic building block Pharmaceutical intermediate

tert-butyl 3-(aminomethyl)-1-oxa-9-azaspiro[4.5]decane-9-carboxylate structure

tert-butyl 3-(aminomethyl)-1-oxa-9-azaspiro[4.5]decane-9-carboxylate

CAS 1160247-18-6

Oxa-azaspiro scaffold Aminomethyl group Spiro heterocyclic building block Pharmaceutical intermediate

3-Bromotetrahydrofuran structure

3-Bromotetrahydrofuran

Tetrahydrofuran scaffold Alkyl bromide Halogenated heterocyclic building block Pharmaceutical intermediate

tert-Butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate structure

tert-Butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate

CAS 142733-64-0

Cyclobutane scaffold Boc-protected amine Protected small-ring amine Pharmaceutical intermediate

3,3-Dimethylcyclobutanecarboxylic acid structure

3,3-Dimethylcyclobutanecarboxylic acid

Cyclobutane scaffold Carboxylic acid Small-ring building block Pharmaceutical intermediate

(cis-3-Aminocyclobutyl)methanol hydrochloride structure

(cis-3-Aminocyclobutyl)methanol hydrochloride

CAS 142733-65-1

Cyclobutane scaffold Alcohol Small-ring amine building block Pharmaceutical intermediate

1-Amino-3-fluorocyclobutanecarboxylic acid structure

1-Amino-3-fluorocyclobutanecarboxylic acid

Cyclobutane scaffold Amino acid Small-ring building block Pharmaceutical intermediate

tert-Butyl5,5-difluoro-2,7-diazaspiro[3.5]nonane-2-carboxylate structure

tert-Butyl5,5-difluoro-2,7-diazaspiro[3.5]nonane-2-carboxylate

CAS 2007920-32-1

Diazaspiro scaffold Boc-protected amine Fluorinated heterocyclic building block Pharmaceutical intermediate

tert-butyl N-[(3-hydroxycyclobutyl)methyl]carbamate structure

tert-butyl N-[(3-hydroxycyclobutyl)methyl]carbamate

CAS 917827-92-0

Cyclobutane scaffold Alcohol Small-ring building block Pharmaceutical intermediate

tert-Butyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)-3-formylazetidine-1-carboxylate structure

tert-Butyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)-3-formylazetidine-1-carboxylate

CAS 1638771-11-5

Azetidine scaffold Aldehyde Protected heterocyclic intermediate Pharmaceutical intermediate

2-oxaspiro[3.3]heptan-6-one structure

2-oxaspiro[3.3]heptan-6-one

CAS 1339892-66-8

Oxaspiro scaffold Ketone Spirocyclic building block Pharmaceutical intermediate

spiro[3.3]heptan-2-one structure

spiro[3.3]heptan-2-one

Spiro[3.3]heptane scaffold Ketone Spirocyclic building block Pharmaceutical intermediate

(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-amine structure

(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-amine

Bridged amine Primary amine Chiral amine building block Pharmaceutical intermediate

methyl azetidine-2-carboxylate;hydrochloride structure

methyl azetidine-2-carboxylate;hydrochloride

CAS 162698-26-2

Azetidine scaffold Hydrochloride salt Heterocyclic building block Pharmaceutical intermediate

5,8-dioxaspiro[3.4]octan-2-ylmethanol structure

5,8-dioxaspiro[3.4]octan-2-ylmethanol

CAS 545882-60-8

Dioxaspiro scaffold Acetal Spirocyclic building block Pharmaceutical intermediate

tert-butyl N-[3-fluoro-1-(hydroxymethyl)cyclobutyl]carbamate structure

tert-butyl N-[3-fluoro-1-(hydroxymethyl)cyclobutyl]carbamate

CAS 1232365-48-8

Cyclobutane scaffold Boc-protected amine Fluorinated small-ring building block Pharmaceutical intermediate

tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate structure

tert-butyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate

CAS 1232365-42-2

Cyclobutane scaffold Boc-protected amine Fluorinated small-ring building block Pharmaceutical intermediate

Methyl 5,8-dioxaspiro[3.4]octane-2-carboxylate structure

Methyl 5,8-dioxaspiro[3.4]octane-2-carboxylate

CAS 1037175-81-7

Dioxaspiro scaffold Acetal Spirocyclic building block Pharmaceutical intermediate

Spiro[2.3]hexan-5-one structure

Spiro[2.3]hexan-5-one

Cyclopropane-cyclobutane system Ketone Small-ring building block Pharmaceutical intermediate

tert-butyl 3-amino-3-(trifluoromethyl)azetidine-1-carboxylate structure

tert-butyl 3-amino-3-(trifluoromethyl)azetidine-1-carboxylate

CAS 1258652-24-2

Azetidine scaffold Boc-protected amine Fluorinated heterocyclic building block Pharmaceutical intermediate

3-aminooxetane-3-carbonitrile;hydrochloride structure

3-aminooxetane-3-carbonitrile;hydrochloride

CAS 1818847-73-2

Oxetane scaffold Hydrochloride salt Heterocyclic building block Pharmaceutical intermediate

3-fluoro-1-propan-2-yloxycarbonylcyclobutane-1-carboxylic acid structure

3-fluoro-1-propan-2-yloxycarbonylcyclobutane-1-carboxylic acid

CAS 1403766-90-4

Cyclobutane scaffold Carboxylic acid Small-ring building block Pharmaceutical intermediate