1-Amino-3,3-difluorocyclobutanecarboxylic acid

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1-Amino-3,3-difluorocyclobutanecarboxylic acid structure
Structural Feature
Cyclobutane scaffold
Reactive Feature
Amino acid Carboxylic acid Difluoro substituted
Synthesis Role
Fluorinated small-ring building block
Application Context
Pharmaceutical intermediate
CAS Number1225532-86-4
Product CodeSL1112034
Molecular FormulaC5H7F2NO2
Molecular Weight151.11
AppearanceOff-white to light brown solid
Melting Point>220 °C
Boiling Point243.4±40.0 °C (Predicted)
Density1.47±0.1 g/cm³ (Predicted)
SMILESNC1(C(=O)O)CC(F)(F)C1
InChIKeyKSCVQJSNYDFHOT-UHFFFAOYSA-N
Description1-Amino-3,3-difluorocyclobutanecarboxylic acid, a gem-difluoro α-amino acid. The gem-difluoro enhances metabolic stability and electrophilicity, used in fluoropeptidomimetic synthesis.
ApplicationsPharmaceutical intermediate; fluorinated; amino acid

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