1-Amino-3,3-difluorocyclobutanecarboxylic acid

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1-Amino-3,3-difluorocyclobutanecarboxylic acid structure
Structural Feature
Cyclobutane scaffold
Reactive Feature
Amino acid Carboxylic acid Difluoro substituted
Synthesis Role
Fluorinated small-ring building block
Application Context
Pharmaceutical intermediate
CAS Number1225532-86-4
Molecular FormulaC5H7F2NO2
Molecular Weight151.11 g/mol
AppearanceOff-white to light brown solid
SMILESNC1(C(=O)O)CC(F)(F)C1
InChIKeyKSCVQJSNYDFHOT-UHFFFAOYSA-N
Description1-Amino-3,3-difluorocyclobutanecarboxylic acid, a gem-difluoro α-amino acid. The gem-difluoro enhances metabolic stability and electrophilicity, used in fluoropeptidomimetic synthesis.
ApplicationsPharmaceutical intermediate; fluorinated; amino acid
Hazard ClassSkin Irrit. 2; Eye Irrit. 2A; STOT SE 3 (Resp)