3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

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3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide structure
Structural Feature
Imidazotetrazine scaffold
Reactive Feature
Carboxamide
Synthesis Role
Alkylating active molecule
Application Context
Active pharmaceutical molecule Antitumor drug related
Número CAS85622-93-1
Fórmula molecularC6H6N6O2
Masa molar194.15 g/mol
AspectoWhite to off-white solid
SMILESCn1nnc2c(C(N)=O)ncn2c1=O
InChIKeyBPEGJWRSRHCHSN-UHFFFAOYSA-N
DescripciónTemozolomide, an imidazotetrazine antineoplastic agent. Spontaneously degrades at physiological pH to generate a methyldiazonium ion that methylates DNA O6-guanine; used for glioblastoma.
AplicacionesAPI; antineoplastic; alkylating agent
Clase de peligroCarc. 1B; Muta. 1B; Repr. 1B; STOT RE 1; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2