4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Zu diesem Produkt anfragen Auftragsynthese eines Analogs
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine structure
Structural Feature
Pyrrolopyrimidine scaffold
Reactive Feature
Heteroaryl chloride
Synthesis Role
Kinase inhibitor building block
Application Context
Pharmaceutical intermediate
CAS-Nummer3680-69-1
SummenformelC6H4ClN3
Molare Masse153.57 g/mol
AussehenWhite crystalline solid
SMILESClc1ncnc2[nH]ccc12
InChIKeyBPTCCCTWWAUJRK-UHFFFAOYSA-N
Beschreibung4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, with 4-chloro as a nucleophilic aromatic substitution handle. Condenses with amines to construct pyrrolopyrimidine drugs; key intermediate for JAK inhibitors like tofacitinib.
AnwendungenPharmaceutical intermediate; pyrrolopyrimidine; JAK inhibitor intermediate
GefahrenklasseAcute Tox. 3 (Oral); Skin Irrit. 2; Eye Irrit. 2; STOT SE 3 (Resp)